Reports continue to use terms, such as “Rare link” and “Rare cases,” and “COVID-19 vaccines have saved millions of lives” to obfuscate the impact of widespread Covid-19 vaccine injuries. I’ve previously suggested in two peer-reviewed, PubMed listed papers (Maguire, 2021; Maguire, 2022) means to develop vaccines for respiratory diseases that better prevent the spread of virions and also reduce the probability of vaccine injury.
As I’ve described in a preprint about Covid-19 vaccine injury, Covid-19 mRNA vaccines use technologies that have never previously been implemented in vaccines. For example, PEG , part of the lipid nano-particle (LNP) containing the mRNA, has never been used before in an approved vaccine. Over 70% of people tested develop antibodies against PEG, and 7% can develop anaphylactic shock. The long term consequences are not understood. Concerning too is that mRNA vaccines may introduce DNA into the host genome, thus potentially introducing viral proteins to the host immune system for extended periods. Unlike what physicians in the media have said (Offit, 2021), humans possess robust reverse transcriptase enzymes that can write RNA sequences into DNA (Chandramouly et al, 2021), and the possibility exists that mRNA vaccines may introduce a DNA message into human genomes (Zhang et al, 2021; Alden et al, 2022). Indeed, free spike antigen was detected in the blood of adolescents and young adults who developed post-mRNA vaccine myocarditis. Individuals who developed postvaccine myocarditis uniquely exhibit elevated levels of free spike protein in circulation, unbound by anti-spike antibodies, which appear to correlate with cardiac troponin T levels and innate immune activation with cytokine release. One study has found the spike protein in circulation of the mRNA vaccinated for 6 months following injection. Circulating spike protein following vaccination originates from endogenous production, and its concentration is therefore likely higher in tissues where production occurs compared to what is observed in the blood. For example, levels of the neurotransmitter dopamine are up to 100 million times higher in brain areas where it is produced, in comparison to plasma where it occurs as a result of tissue spillover. Thus, if spike protein is being made because the mRNA vaccination became incorporated into our DNA, then measuring spike protein in our blood may not be the best indicator. More work is required to provide good evidence whether this is happening long term in vaccinated humans through incorporation into the DNA (Doerfler, 2021). Understand, that if your body is continuously making Covid-19 spike proteins, chronic activation of your innate and adaptive immune systems and related inflammation may be occurring. Also understand that these vaccines don’t stop or reduce transmission of the disease, but masks do. If you want to avoid Covid-19 infection, wear an effective mask, such as N95 or KN95, socially distance, and avoid places with poor ventilation.
Also, although chemical modifications in the RNA molecules used in vaccines are intended to decrease TLR (toll-like receptor) sensing of external single-stranded RNAs, and thus triggering proinflammatory signals, there is some evidence that modified uracil residues do not completely abrogate TLR detection of the mRNA. Also, while efforts are made to reduce proinflammatory double-stranded (ds) RNA production, there may be small amounts of dsRNA that can occasionally be packaged within mRNA vaccines. Further, inflammatory responses can be exacerbated on a background of pre-existing inflammatory conditions, as was recently shown in a mouse model after administration of mRNA–LNPs. This effect was found to be specific to the LNP, acting independently of the mRNA cargo. Given compounding inflammation with each dose, frequent booster immunizations may increase the frequency and/or the severity of the reported AEs. An informative review of this is available.
As Danice Hertz, MD has written in a response to an article about Long Covid, “There
are many thousands of people who have suffered a similar neurological syndrome as a
result of receiving a Covid vaccine. I am one of those people and have severe
neuropathic pain from head to toe as well as tinnitus, dizziness, imbalance, blurred
vision, fatigue, headaches for 14 months now. Many of us have been diagnosed with
small fiber neuropathy, dysautonomia and mast cell activation syndrome. It is time that
these vaccine reactions be acknowledged, and that research be conducted to help
understand the mechanism of injury so better treatments can be available to help those
like me who have suffered terrible injury from the vaccines” (George, 2022). Recently,
Gregory Poland, MD, director of the Mayo Clinic’s Vaccine Research Group in
Rochester, Minnesota, reported his severe tinnitus after receiving the second dose of a
mRNA covid-19 vaccine. “It was like someone suddenly blew a dog whistle in my ear,”
Poland told MedPage Today. “It has been pretty much unrelenting.” Since then, Poland
said he has been experiencing what he describes as life-altering tinnitus. Commenting
on his symptoms, he “can only begin to estimate the number of times I just want to
scream because I can’t get rid of the noise or how many hours of sleep I’ve lost,”
(Henderson, 2022). Dr. Hertz has also made comments at FDA meetings about these vaccines.
Quoting from Scorza and Finisterer (2021), “Real world data rather indicate that the
spectrum of side effects to any of the commercially available SARS-CoV-2 vaccinations
is broader than anticipated, underreported, and played down. Side effects need to be
thoroughly elaborated to draw more real pictures than those frequently sold. Real world
is more unsafe than its propagated image.” The role of vaccines in inducing
autoimmune disease needs to be studied (Chen et al, 2001; Toussirot and Bereau,
2015; Principi and Esposito, 2020; Chen et al, 2022).
Autoimmune encephalitidies ((Zlotnik et al, 2021), venous sinus thrombosis (Finisterer
and Nics, 2021; Sharifian-Dorche et al, 2021), intracranial hemorrhage with venous
sinus thrombosis occurring in the same patient (Purkayastha et al, 2021), and glial
fibrillary acidic protein astrocytopathy (GFAP-A) can result following the second dose of
an mRNA vaccine (Koh et al, 2022). Autoimmune encephalitis is difficult to diagnose
with current clinical diagnostics and therefore often goes untreated (Graus et al, 2016).
Autoantibodies can persist for at least 6 months following even mild Covid-19 disease
(Liu et al, 2021; Su et al, 2022). Neurological symptoms will result (Patone et al, 2021;
Finisterer, 2022), including memory and attention deficits for up to 9 months (Zhao et al,
2022), and brain autoimmunity with attack of myelin in neurons may result (Gupta and
Weaver, 2021; Shabani, 2021). Autoantibodies acting on vascular endothelial cells
(Bouillet et al, 2013) in the part of the blood supply that feeds the brain, can cause
thrombotic thrombocytopenia (Zuo et al, 2020; Gunther et al, 2021), and cerebral
venous sinus thrombosis (Finsterer, 2021), and may also underlie the generalized
report of “brain fog” in such patients and other forms of encephalopathy (Huang and
Huang, 2022). Recent studies have found that spike proteins in SARS-CoV-2 attach to
vimentin (Amraei et al, 2022), which is present at the extracellular surface of endothelial
cells. This is a possible mechanism underlying the vaccine induced vascular
abnormalities. Autoantibodies are also known to attack neutrophils, a key component of
the innate immune response, and therefore could be an important reason for severe
Covid-19 in those with autoimmune disease, potentially even that induced from
vaccination (Weiner and Segelmark, 2016). Douaud et al (2022) found that Covid-19
whether severe or non-severe (not hospitalized), have significant brain damage.
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